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AOD-9604 is a modified fragment of human growth hormone (hGH amino acids 177-191) with an N-terminal tyrosine, developed by Professor Frank Ng at Monash University in collaboration with Metabolic Pharmaceuticals Ltd (Australia). It stimulates lipolysis and inhibits lipogenesis through beta-3 adrenergic receptor upregulation without the growth-promoting effects of full hGH. Six clinical trials enrolling ~900 participants demonstrated excellent safety but the pivotal Phase IIb trial failed to show clinically meaningful weight loss, leading to development termination in 2007. Australia’s TGA has approved it as iTRAM for intra-articular knee osteoarthritis. It is not FDA-approved and is WADA-prohibited.
Stimulates fat loss through lipolysis without growth hormone side effects. Does not increase IGF-1, affect glucose metabolism, or cause insulin resistance. Also shows promise for cartilage repair. Note: subcutaneous injection is community-derived — all six clinical trials used oral dosing.
AOD-9604 acts through a dual mechanism: acutely, it stimulates lipolysis and energy expenditure through receptor-independent pathways; chronically, it upregulates beta-3 adrenergic receptor (β3-AR) expression in adipose tissue (restoring levels to lean-equivalent) to sustain fat oxidation. This was confirmed by knockout mouse studies where acute effects persisted but chronic weight loss was abolished without β3-AR. Crucially, it does not bind the GH receptor, does not increase IGF-1, and does not cause hyperglycemia or cell proliferation.
Fat Loss
Fat Loss / Lipolysis
Primary research indication. Increases fat oxidation, plasma glycerol levels, and reduces body weight in obese models without affecting glucose metabolism.
Lipogenesis Inhibition
Reduces fat synthesis and storage in adipose tissue. Effects demonstrated in both animal models and isolated human adipose tissue.
Metabolic Safety
Unlike full hGH, does not cause hyperglycemia, reduce insulin secretion, or increase insulin resistance. Safer metabolic profile.
Joint
Cartilage Repair
Emerging indication. Combined with hyaluronic acid, showed enhanced cartilage regeneration in osteoarthritis models.
Joint Health
Accelerated lameness recovery in animal studies. Does not stimulate IGF-1, potentially safer for joint applications.
Osteoarthritis
Research shows synergistic effects with HA for OA treatment. May support joint repair without growth-promoting risks.
Lyophilized (freeze-dried) peptides should be stored in a refrigerator at 2–8°C (36–46°F). For long-term storage, they should be kept in a freezer at -20°C (-4°F) or below. Once reconstituted, peptides must be stored in a refrigerator at 2–8°C (36–46°F) and should not be left at room temperature for extended periods.
Add 2mL of bacteriostatic water to get a solution that is 5mg/mL, such that every 0.1mL (10 units on an insulin syringe) is equal to 500mcg of AOD-9604 (10mg).
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Roy Brandt
I run a low dose, around 100mcg daily (injected). It helps me sleep because apnea is reduced but it seems to make weight loss more about fat than about my body eating muscle. It seems to have near zero side effects other than a mild headache if you’ve been off it for a while and that’s barely even a thing. Health is wealth!
JourneyWithPeptides
I did two cycles totaling 10 weeks and lost 3 inches off my waist. All within a healthy BMI, so I was pretty impressed. I did 250mcg 2x a day.
Marianne W
I started researching AOD while working on my overall body-composition goals. For me, the biggest change has been becoming more consistent with my nutrition, exercise, and wellness routine. I’m taking things one step at a time and really enjoying the journey with AOD being a part of it
Mark Twingale
Im using Noxs AOD and Motsc currently. The AOD helps with the insulin levels and helping my body burn fat instead of the sugars in my body. I’ve just gotten into power lifting this year, used Reta before to get the my desired BMI and now im trying to gain muscle mass through having the right diet and eating clean food to burn fat. So far so good i feel great, im also using Test from Nox and its very pure. I highly recommend !