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What is HGH (Somatropin)?
Human Growth Hormone (HGH), also known as somatropin or somatotropin, is a 191 amino acid single-chain polypeptide hormone naturally produced by the anterior pituitary gland. Recombinant HGH (rhGH/somatropin) is bioidentical to endogenous growth hormone and is FDA-approved for growth hormone deficiency in children and adults, as well as several other conditions. The ‘191aa’ designation refers to its complete 191 amino acid structure, distinguishing it from older 192aa formulations. HGH regulates growth, metabolism, body composition, and numerous physiological processes through direct actions and via stimulating IGF-1 production.
Key Benefits
Improved body composition (increased lean mass, decreased fat mass), enhanced bone mineral density, improved lipid profile, increased exercise capacity, better quality of life and mood, skin and hair improvements, enhanced recovery and healing
Mechanism of Action
HGH binds to GH receptors on target tissues, triggering JAK2-STAT5 signaling pathway. Direct effects include lipolysis, protein synthesis stimulation, and metabolic regulation. Indirect effects occur via IGF-1 stimulation in liver and peripheral tissues, promoting growth, cell proliferation, and anabolism. Half-life: ~3 hours subcutaneously; peak levels 3-5 hours post-injection.
Approved Uses
Pediatric Growth Hormone Deficiency
FDA-approved for children with GHD, including idiopathic and organic causes. Also approved for Turner syndrome, Prader-Willi syndrome, SGA, Noonan syndrome, SHOX deficiency, and chronic renal insufficiency
Adult Growth Hormone Deficiency
FDA-approved for adults with GHD from childhood-onset or adult-onset causes including pituitary tumors, surgery, radiation, or trauma. Requires biochemical confirmation
HIV-Associated Wasting
FDA-approved indication for treatment of HIV-associated wasting/cachexia to increase lean body mass and body weight
Off Label Research
Anti-Aging / Wellness
Research interest in age-related GH decline. Benefits on body composition, skin, and energy observed but FDA does not approve for anti-aging. Risks may outweigh benefits in healthy adults
Athletic Performance
Used off-label for performance enhancement. Increases lean mass and reduces fat but evidence for actual performance improvement is limited. Banned by WADA and most sports organizations
Injury Recovery
Research suggests potential benefits for tendon, ligament, and tissue healing. Used in some clinical settings for recovery from surgery or injury
Body Composition
Fat Mass Reduction
Consistently demonstrated reduction in fat mass, particularly visceral/central adiposity, through enhanced lipolysis and metabolic rate
Lean Mass Increase
Meta-analyses confirm statistically significant increases in lean body mass with GH treatment, supporting improved muscle function
Improved Body Composition Ratio
Overall improvement in lean-to-fat ratio even without significant changes in total body weight
Lyophilized (freeze-dried) peptides should be stored in a refrigerator at 2–8°C (36–46°F). For long-term storage, they should be kept in a freezer at -20°C (-4°F) or below. Once reconstituted, peptides must be stored in a refrigerator at 2–8°C (36–46°F) and should not be left at room temperature for extended periods.
Add 1.2mL of bacteriostatic water to get a solution that is 12IU/mL, such that every 0.1mL (10 units on an insulin syringe) is equal to 1IU of HGH.
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