VIP (10mg)

Immunity
VIP (10mg)
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What is VIP?

Vasoactive Intestinal Peptide (VIP) is a 28-amino acid neuropeptide with potent anti-inflammatory, immunomodulatory, and neuroprotective properties. Acting through VPAC1 and VPAC2 receptors, VIP regulates immune function, vascular tone, circadian rhythms, and neurological health. It has been extensively studied for chronic inflammatory response syndrome (CIRS), pulmonary conditions, autoimmune diseases, and most recently COVID-19 respiratory failure. The injectable form (Aviptadil/Zyesami) received FDA Fast Track designation for COVID-19 ARDS.

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Every NØX product is released through a controlled quality framework verifying identity, purity, consistency, endotoxin levels, and heavy metal content. Each batch undergoes analytical testing to confirm peptide composition prior to distribution, including independent laboratory verification using chromatographic and mass spectrometry methods. Only batches that pass internal quality review and release authorization enter circulation, reflecting our commitment to rigorous testing, documentation, traceability, and the continuous pursuit of uncompromising quality.

Lab Reports

Freedom Diagnostics
Freedom Diagnostics
Avg Purity: 99.37%
Avg Mass: 9.39mg
Result Date: August 27, 2026
Search Code: NOXP2608240611
Lot: NX-VP50

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Description

What is VIP?

Vasoactive Intestinal Peptide (VIP) is a 28-amino acid neuropeptide with potent anti-inflammatory, immunomodulatory, and neuroprotective properties. Acting through VPAC1 and VPAC2 receptors, VIP regulates immune function, vascular tone, circadian rhythms, and neurological health. It has been extensively studied for chronic inflammatory response syndrome (CIRS), pulmonary conditions, autoimmune diseases, and most recently COVID-19 respiratory failure. The injectable form (Aviptadil/Zyesami) received FDA Fast Track designation for COVID-19 ARDS.

Key Benefits

Systemic anti-inflammatory and immunomodulatory effects, precise dosing control, rapid onset of action, established safety in clinical trials. Used for systemic inflammation, autoimmune conditions, and when nasal route is insufficient.

Mechanism of Action

SubQ/IM VIP provides systemic exposure activating VPAC1/VPAC2 receptors throughout the body. Triggers cAMP/PKA signaling cascade, suppresses pro-inflammatory cytokines (IL-6, TNF-α, IL-1β), modulates T helper cell differentiation, and provides vasodilatory effects. Short half-life (5-10 min SubQ) may require multiple daily doses.

Inflammatory

  • Systemic Inflammation
    VIP significantly reduced IL-6 inflammatory marker in clinical trials. Potent suppressor of pro-inflammatory cytokines through VPAC receptor activation.
  • Autoimmune Disease
    IP injection completely prevented joint destruction in collagen-induced arthritis models. Downregulates both inflammatory and autoimmune disease components.
  • CIRS (Systemic Approach)
    Injectable VIP provides systemic immunomodulation when nasal delivery is insufficient or for patients requiring higher systemic levels.

Respiratory

  • COVID-19 ARDS
    Phase 2b/3 trial showed 2-fold increased 60-day survival odds with IV Aviptadil. Mechanically ventilated patients showed 10-fold survival improvement.
  • Pulmonary Inflammation
    VIP protects alveolar type II cells, reduces pulmonary inflammation, and has bronchodilatory effects in respiratory conditions.
  • Pulmonary Arterial Hypertension
    VIP causes selective pulmonary vasodilation and improved cardiac output. VIP deficiency linked to PAH development.

Vascular

  • Vasodilation
    VIP is one of the most potent endogenous vasodilators. Useful in conditions requiring improved blood flow.
  • Vascular Remodeling
    VIP administration attenuates pathological vascular remodeling in pulmonary hypertension models.
  • Tissue Perfusion
    Vasodilatory effects improve tissue perfusion and may complement healing in various conditions.

Lyophilized (freeze-dried) peptides should be stored in a refrigerator at 2–8°C (36–46°F). For long-term storage, they should be kept in a freezer at -20°C (-4°F) or below. Once reconstituted, peptides must be stored in a refrigerator at 2–8°C (36–46°F) and should not be left at room temperature for extended periods.

Add 2mL of bacteriostatic water to get a solution that is 5mg/mL, such that every 0.1mL (10 units on an insulin syringe) is equal to 0.5mg of VIP.

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VIP (10mg)
VIP (10mg)
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